Your Complete Detox Supplement Companion Guide
Pathway-matched supplement recommendations for every phase of detox.
If you took the questionnaire and felt a little overwhelmed — or maybe a little relieved that there's finally a name for what you've been feeling — this guide is for you. You don't have to overhaul your life overnight. You don't have to buy everything on this page. You just have to start somewhere, with the one pathway your body has been whispering loudest about.
How to Read This Guide
Good — A helpful, foundational option; appropriate place to start. Better — More targeted to this pathway; adds meaningful clinical depth. Best-Fit — The highest-leverage product for this specific pathway.
Where to Buy: NutriDyn
Visit nutridyn.com/profile to create an account and order. Secoya Health's practitioner code is 102828 — enter it when creating your 'patient' account.
Visit NutriDynThe Spark
Phase I — CYP450
Your unpacking crew is either running too hot or too cold. Our goal is to balance it, cool the oxidative fire, and reduce what's overwhelming it.
Detox Support
Plant-based Phase I modulator with green tea, milk thistle, and pomegranate. Gentlest entry point and ideal for highly sensitive people.
How to use: 2 capsules daily with food.
Liposomal Glutathione
Quenches the reactive intermediates Phase I produces before they cause damage. Liposomal form absorbs far better than standard glutathione.
How to use: 1 dropperful, 1–2× daily. Refrigerate.
Detox Phase I & II
The comprehensive formula for this pathway with calcium-D-glucarate, NAC, milk thistle, ALA, DIM, and more. Supports both Phase I modulation and Phase II conjugation simultaneously.
How to use: 3 capsules daily with food.
Simplest starter stack
Detox Support + Liposomal Glutathione → graduate to Detox Phase I & II when ready.
The Messenger
2A Methylation — COMT, MTHFR
Your methyl-donor tank is low. We're going to refill it gently, because over-methylating can feel worse before it feels better.
Methyl Support
Core methylation support: L-5-MTHF, B6, B12, riboflavin. Lighter formula and an ideal starting point for those new to methylation support.
How to use: As directed on label.
Magnesium Glycinate
Magnesium is a required cofactor for COMT. Glycinate form is calming and well-tolerated. Supports methylation and nervous system regulation.
How to use: 2 capsules, 1–2× daily.
Methyl Complete
The most comprehensive methylation formula in the NutriDyn line with active L-5-MTHF, methylcobalamin B12, NAC, and betaine (TMG) to directly bypass MTHFR sluggishness.
How to use: 2 capsules daily. Start with 1 if sensitive.
Simplest starter stack
Methyl Support + Magnesium Glycinate. Graduate to Methyl Complete after 2–3 weeks if you tolerate it well.
Tender tip
If B-vitamins have historically made you feel anxious or wired, start with a fraction of the dose and build slowly. That reaction is real, common, and manageable.
The Sealer
2B Sulfation — SULT
Your sulfur-handling pathway is overloaded. We're giving it raw sulfur materials, key cofactors, and NRF2 signaling support.
Pure Taurine
Pharmaceutical-grade taurine powder (2 g per ¼ tsp). Taurine is a key sulfur-containing amino acid that directly supports sulfation and bile acid conjugation.
How to use: ¼ tsp (2 g) daily in water.
MSM Complex
800 mg MSM (methylsulfonylmethane) plus vitamin C (as magnesium ascorbate) which directly replenishes organic sulfur, the primary raw material this pathway needs.
How to use: 1–3 capsules daily.
MSM Complex + Sulforaphane Complex
MSM refills the sulfur pool; Sulforaphane Complex (700 mg EnduraCell® broccoli sprout + selenium 25 mcg) activates NRF2 to turn on Phase II sulfation enzymes. Together they address both the fuel and the machinery.
How to use: MSM: 1–3 caps daily. Sulforaphane: 1 cap daily.
Simplest starter stack
MSM Complex alone as a starting point. Add Sulforaphane Complex as the second layer.
Tender tip
Daily Epsom salt baths are an inexpensive, transdermal sulfate source and a beautiful, low-cost adjunct to this stack.
The Gift-Wrapper
2C Glucuronidation — UGT
Your body is struggling to wrap up hormones and medications for safe export. This is the pathway behind many "estrogen-dominance" stories.
Fiber
Non-negotiable foundational support which binds conjugated hormones in the gut so they leave in stool instead of recirculating.
How to use: 1 scoop in 10–12 oz water daily.
I-3-C Plus
150 mg DIM + 150 mg indole-3-carbinol which directs estrogen metabolism toward safer 2-OH pathway and away from the more reactive 4-OH and 16-OH pathways.
How to use: 1–2 capsules daily with food.
Calcium D-Glucarate Plus + Fiber
Calcium-D-glucarate inhibits beta-glucuronidase, the enzyme that "unwraps" hormones you've already tagged for export so they actually leave. Fiber then escorts them out. This two-product combination is the most clinically targeted stack for this pathway.
How to use: Calcium D-Glucarate: as directed. Fiber: 1 scoop daily.
Simplest starter stack
Fiber + I-3-C Plus. Add Calcium D-Glucarate Plus when you're ready for the most complete approach.
The Bodyguard
2D Glutathione — GST
Your master antioxidant is depleted — often from a lifetime of carrying a big load. This is not weakness; it's evidence of how much you've handled.
Essential Minerals
Provides selenium 150 mcg (272% DV) which is a required cofactor for glutathione peroxidase (your antioxidant recycling system), plus zinc and molybdenum.
How to use: 4 capsules daily.
Nutri-ChelX
Contains NAC 500 mg (glutathione precursor) + ALA 150 mg + quercetin 425 mg + selenium + methylfolate/B12. A comprehensive antioxidant/chelation-support formula that rebuilds glutathione from the ground up.
How to use: 2 capsules daily.
Liposomal Glutathione + Nutri-ChelX
Liposomal glutathione provides direct, cell-ready delivery (bypassing absorption barriers); Nutri-ChelX provides the NAC, selenium, and cofactors to keep making glutathione. Together they address both immediate replenishment and sustained production.
How to use: Liposomal Glutathione: 1 dropperful 2× daily. Nutri-ChelX: 2 caps daily.
Simplest starter stack
Liposomal Glutathione + Essential Minerals. Add Nutri-ChelX for deeper rebuilding.
Tender tip
If you feel worse when you start glutathione, that often means The Exit (Phase III) needs attention first. Scroll down and start there instead.
The Stamp
2E Acetylation — NAT + Histamine
You're likely a slow acetylator. We're going to reduce the load, support cofactors, and if histamine is a central theme add targeted DAO enzyme support.
Essential Minerals
Provides the mineral foundation (zinc, selenium, molybdenum) that NAT enzymes and downstream methylation depend on.
How to use: 4 capsules daily.
Methyl Complete
Histamine is cleared in part by methylation (via HNMT enzyme). Supporting COMT and HNMT with methyl donors is a meaningful upstream strategy for histamine and slow acetylation.
How to use: 2 capsules daily.
Histamine Digest™ (Seeking Health)
The only product in this guide that provides DAO (diamine oxidase) — the enzyme your gut uses to break down food-derived histamine before it causes symptoms. Patented DAO2 enzyme. This is the true gap in the NutriDyn line, and Seeking Health's product is the gold standard on the professional market.
How to use: 1 capsule 15–20 minutes before eating histamine-containing foods or meals.
Outside NutriDyn — Practitioner-Exclusive. Available through Fullscript or Seeking Health's practitioner channel.
Simplest starter stack
Essential Minerals + Methyl Complete. If histamine symptoms are prominent (headaches after wine, leftovers, aged cheese, fermented foods), add Histamine Digest.
Tender tip
DAO enzymes work only on food-derived histamine in the gut. They do not address mast cell activation or endogenous histamine release. Those patients need a different, more comprehensive conversation.
The Peacekeeper
2F Amino Acid Conjugation — Glycine
Your glycine pool is running low. Glycine is both a detox tag and your body's "calm down" signal, which means replenishing it often feels like finally exhaling.
Magnesium Glycinate
A foundational two-for-one with a meaningful glycine source paired with calming magnesium. Best for milder presentations or as a sleep aid.
How to use: 2 capsules, 1–2× daily (often best at night).
Methyl Complete
Supports upstream methylation that feeds glycine synthesis and neurotransmitter balance. This is especially helpful when the "wired-but-tired" picture has a methylation component.
How to use: 2 capsules daily.
Pure Glycine + Magnesium Glycinate
Pure Glycine (pharmaceutical grade, 500 mg per capsule) taken alongside Magnesium Glycinate allows meaningful glycine loading. For higher therapeutic dosing (3–5 g daily), taking 6+ capsules is an option though a glycine powder format would be more economical at those levels. This two-product stack is the most direct NutriDyn approach.
How to use: Pure Glycine: 1–3 caps (500–1,500 mg) daily. Magnesium Glycinate: 2 caps nightly.
Simplest starter stack
Magnesium Glycinate at night + bone broth or collagen powder daily. This combination is often the single most calming thing a burned-out nervous system has received in years. 🌿
The Exit
Phase III — Transport & Elimination
Your exit doors are backed up and everything upstream is re-circulating. Start here first even if another section scored high because detox without drainage makes everything worse.
Fiber
The anchor. Binds conjugated toxins and hormones in the gut, bulks stool, and feeds beneficial bacteria. Non-negotiable for this pathway.
How to use: 1 scoop in 10–12 oz water daily. Work up slowly to avoid gas.
Fiber + Magnesium Glycinate
Fiber opens the door; magnesium gently supports bowel motility at night. Together they address both bulk and muscle tone in the bowel.
How to use: Fiber: 1 scoop daily. Magnesium: 2 caps at bedtime.
Fiber + Magnesium Glycinate + Digestive Complete + LV-GB Complex™
This four-part combination addresses every layer of Phase III: stool bulk, motility, enzymatic digestion, and bile flow. LV-GB Complex (Designs for Health) provides ox bile, taurine, artichoke, milk thistle, methionine, inositol, and B vitamins — broad-spectrum bile support.
How to use: Fiber + Magnesium as above. Digestive Complete: 1–2 caps with meals. LV-GB Complex: 3 caps daily with meals.
LV-GB Complex is practitioner-exclusive through Designs for Health (Fullscript or Wellevate). TUDCA standalone (250–750 mg/day) is another option for patients needing higher-potency bile support.
Simplest starter stack
Fiber + Magnesium Glycinate as the starting point for anyone. Add Digestive Complete + LV-GB if fat digestion or bile is clearly an issue.
Tender tip
Binders (like NutriDyn's Binder Pro) should only be added once bowel movements are regular and daily. Using binders with constipation creates a worse backup.
The "If I Could Only Afford Three Things" Starter Stack
If budget is tight and you want the highest-leverage trio for nearly any pathway:
Fiber
opens the back door so anything you detox actually leaves.
Magnesium Glycinate
calms the nervous system, supports motility, feeds glycine pathway.
Liposomal Glutathione
the master antioxidant that supports almost every other pathway simultaneously.
This trio covers elimination, calm, and cellular protection — the three pillars underneath every detox story. Add LV-GB Complex for bile support. Open the exits first and everything else works better once drainage is flowing.
Supplements are helpers. They are not heroes. The real work of healing still happens in your kitchen, your bedroom, your nervous system, and your relationships. No capsule can outperform consistent sleep, clean water, daily bowel movements, movement, sunlight, and nourishing food. But when a pathway is truly depleted, giving it the raw material it's been missing can feel like turning a porch light back on after years of stumbling in the dark. You deserve that light.
Not Sure Which Pathway to Start With?
Take our 5-minute detox assessment to find out which of your 8 pathways is asking for support first.
Take the Detox QuizThis guide is for educational purposes only and is not a substitute for personalized medical care. Product availability, formulations, and dosing guidance may change — always check current labels. Practitioner-exclusive products are available through professional dispensary channels such as Fullscript or Wellevate, not general retail. Call or text us at (651) 738-7800 or email heal@secoyahealth.com. If you are pregnant, nursing, on prescription medications, or managing a medical condition, please consult your qualified practitioner before beginning any supplement.